Interactive 3D Model
How Cannabis Affects the Brain
Rotate the brain and click any glowing region — or search below — to see how cannabis acts on it, and compare the effects of THC and CBD.
THC — psychoactive CBD — non-intoxicating
Explore the eight regions ↓The eight regions
Each region of the brain has a different density of CB1 receptors — and responds to cannabis in its own way. Pick one to dive in.
The Big Picture
THC vs CBD
- THC
- Activates CB1 receptors directly — densest in the cerebellum, hippocampus, and basal ganglia.
- CBD
- Acts indirectly, often through serotonin pathways, and frequently counters THC's effects.